Centre for Cell and Gene Therapies (CCGT)

 


The Westmead Research Hub
Centre for Cell and Gene Therapies (CCGT) is based on one of the largest healthcare and research precincts in the Southern hemisphere which encompasses two Area Health Services and three Medical Research Institutes.  The CCGT provides a seamless integration of the extensive knowledge, expertise and facilities of the following organisations:

·         The Children’s Hospital at Westmead

·         Children’s Medical Research Institute

·         Westmead Hospital

·         Westmead Mellenium Institute

·         Kids Research Institute

Cell and gene-based therapeutics are rapidly evolving treatment modalities with immense potential to improve human health.  Unlike other forms of medical practice they require highly specialised laboratory skills and purpose-built facilities in combination with research-based medical care.

 

The CCGT has the largest clinical and research experience in cell and gene-base therapeutics in Australia, with capacity to support third party investigators through access to our template for success and in-house facilities. These facilities include fully commissioned state-of-the-art aseptic and aseptic/bio-contained gene and cellular therapeutics manufacturing suites with immediately available capacity.

 

The services and research programs undertaken by CCGT include:

·         The largest blood and marrow stem cell transplantation laboratory in NSW and one of the largest in Australia.  The laboratory supports a wide variety of complex stem cell procedures including CD34+ stem cell selection, cord blood and haploidentical transplantation in addition to standard autologous and allogeneic stem cell processing.  The laboratory is NATA accredited to AS ISO 15189.

·         Active clinical trials involving adoptive immunotherapy of T cells for opportunistic infection. Trials have been recruiting for over 5 years and represent the only clinical trials of their type in Australasia. At present, trials focus on the treatment of life-threatening CMV disease, post-transplant lymphoproliferative disease (PTLD) due to the EB virus and disseminated adenovirus in stem cell transplant recipients.

·         The second largest renal transplant unit in NSW.

·         The first Clinical Islet Transplant Unit in Australia and only facility in NSW and one of only 22 institutions world-wide to have performed more than 5 islet transplants for Type 1 diabetes.

·         The largest and most productive research program in xenotransplantation (the transplantation of pig organs into humans) in Australia. 

·         The largest and most productive gene therapy research program in Australia.

The CCGT has four propose built clean rooms specifically designed to meet GMP requirements for cellular processing, manipulation and cryopreservation.  The CCGT provides access to world renowned experts at a scientific and clinical level as well as a robust quality system in an environment dedicated to patient care, learning and advancement of Cell and Gene Therapies into the future.




Primary Contact details:

Mr Richard Makin

Quality Manager 

Westmead Research Hub

Darcy Road

Westmead NSW 2145

p:+612 9845 3098

f: +612 9845 3078

email: richarm2@chw.edu.au


Additional contacts

 

Professor Ian Alexander

Head

Gene Therapy Research Unit

The Childrens’ Hospital at Westmead

p:+612 9845 3071

f: +612 9845 3031

email: iana@chw.edu.au

 

Professor David Gottlieb

Director

Sydney Cellular Therapies Laboratory

Westmead Hospital

p:+612 9845 6033

f: +612 9687 2331

Email: david_gottlieb@wmi.usyd.edu.au

 

Professor Philip O’Connell

Director
Centre for Transplant and Renal Research

Westmead Hospital

p:+612 9845 6962

f: +612 9633 9351

email: philip_oconnell@wsahs.nsw.gov.au